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Nek2 ( NIMA ‐related kinase 2) is a serine‐threonine kinase and human homolog of the mitotic regulator  NIMA  of Aspergillus nidulan. We reported the efficiency of Nek2 si RNA  in several cancer xenograft models using cholangiocarcinoma, breast cancer and colorectal cancer. Pancreatic cancer is difficult to treat due to its rapid progression and resistance to chemotherapy. Novel treatments are urgently required to improve survival in pancreatic cancer, and si RNA  are a promising therapeutic option. However, finding an  in vivo  drug delivery system of si RNA  remains a major problem for clinical application. In this study, the overexpression of Nek2 was identified in pancreatic cancer cell lines. Nek2 si RNA  inhibited tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolonged the survival time in an intraperitoneal xenograft mouse model and efficiently prevented the progression of liver metastasis using a portal venous port–catheter system. Taken together, Nek2 is an effective therapeutic target in pancreatic cancer. An adequate delivery system is considered important in treating advanced pancreatic cancer, such as peritoneal dissemination and liver metastasis. Further investigations are required on the safety and side effects of the portal venous port–catheter system. We hope that Nek2 si RNA  will be a novel therapeutic strategy for pancreatic cancer with liver metastasis and peritoneal dissemination.

Nek2 siRNA therapy using a portal venous port–catheter system for liver metastasis in pancreatic cancer