Open AccessThe Wnt7's Tale: A story of an orphan who finds her tie to a famous family
Author(s) -
Noda Makoto,
Vallon Mario,
Kuo Calvin J.
Publication year - 2016
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12924
Subject(s) - wnt signaling pathway , zebrafish , angiogenesis , biology , cloning (programming) , microbiology and biotechnology , reporter gene , genetics , gene , gene expression , signal transduction , programming language , computer science
The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR 124/ TEM 5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008–2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood–brain barrier formation.