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Epithelial–mesenchymal transition ( EMT ) has been closely related with invasive and metastatic properties of cancer. Recently, the convergence of  DNA  damage response and  EMT  in cancer development has received a great amount of scientific attention. Here, we showed that  EMT  is induced by the downregulation of  RAP 80, a well‐known regulator for  DNA  damage response. The knockdown of  RAP 80 leads to  EMT ‐like morphological changes and the increase of tumor sphere formation in non‐adhesive culture. Mechanistically,  RAP 80 controls a reciprocal regulatory axis of  ZEB 1 (for  EMT  activation) and miR200c (for  EMT  inhibition). The downregulation of  RAP 80 increases  ZEB 1 protein and decreases miR200c expression to activate  EMT  signaling in the form of drastic inhibitions of E‐cadherin, p16 and p21 expression. Using  in vivo  metastasis analysis,  RAP 80 knockdown cells are shown to dramatically metastasize into the lung and generate more malignant phenotype compared to controls. Interestingly, the expression level of  RAP 80 was positively correlated with the survival rate in lung adenocarcinoma and breast cancer patients. These findings indicate that  RAP 80 is a critical gatekeeper in impeding  EMT ‐induced metastasis and malignant phenotypes of cancer as well as preserving  DNA  integrity.

RAP80 regulates epithelial–mesenchymal transition related with metastasis and malignancy of cancer