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Cell surface carbohydrates are important for cell migration and invasion of prostate cancer ( PC a). Accordingly, the I‐branching  N ‐acetylglucosaminyltransferase ( GCNT 2) converts linear i‐antigen to I‐branching glycan, and its expression is associated with breast cancer progression. In the present study, we identified relationships between  GCNT 2 expression and clinicopathological parameters in patients with  PC a. Paraffin‐embedded  PC a specimens were immunohistochemically tested for  GCNT 2 expression, and the roles of  GCNT 2 in  PC a progression were investigated using cell lines with high  GCNT 2 expression and low  GCNT 2 expression.  GCNT 2‐positive cells were significantly lesser in organ‐confined disease than in that with extra‐capsular extensions, and  GCNT 2‐negative tumors were associated with significantly better prostate‐specific antigen‐free survival compared with  GCNT 2‐positive tumors. Subsequent functional studies revealed that knockdown of  GCNT 2 expression in  PC a cell lines significantly inhibited cell migration and invasion.  GCNT 2 regulated the expression of cell surface I‐antigen on the  O ‐glycan and glycolipid. Moreover, I‐antigen‐bearing glycolipids were subject to α5β1 integrin–fibronectin mediated protein kinase B phosphorylation. In conclusion,  GCNT 2 expression is closely associated with invasive potential of  PC a.

I‐branching N ‐acetylglucosaminyltransferase regulates prostate cancer invasiveness by enhancing α5β1 integrin signaling