Open AccessMatrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis
Author(s) -
You Yiwen,
Shan Ying,
Chen Jing,
Yue Huijun,
You Bo,
Shi Si,
Li Xingyu,
Cao Xiaolei
Publication year - 2015
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12818
Subject(s) - microvesicles , nasopharyngeal carcinoma , metastasis , matrix metalloproteinase , angiogenesis , cancer research , medicine , cancer , cancer cell , microrna , biology , radiation therapy , biochemistry , gene
Nasopharyngeal cancer ( NPC ) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients. Increasing evidence indicates that exosomes play a pivotal role in promoting cancer metastasis by enhancing angiogenesis and ECM degradation. Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tumors and increases the risk of metastasis. However, little is known about the potential role of MMP 13‐containing exosomes in NPC . In this study, we found that MMP 13 was overexpressed in NPC cells and exosomes purified from conditioned medium ( CM ) as well as NPC patients’ plasma. Transwell analysis revealed that MMP 13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, si RNA inhibited the effect of MMP 13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP 13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.