Open AccessNon‐autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis
Author(s) -
Enomoto Masato,
Vaughen John,
Igaki Tatsushi
Publication year - 2015
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12816
Subject(s) - biology , niche , tumor progression , carcinogenesis , metastasis , drosophila (subgenus) , mutation , genetic screen , tumor microenvironment , tumor initiation , cancer research , genetics , cancer , microbiology and biotechnology , gene , phenotype , ecology
Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non‐autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non‐autonomous overgrowth. Such “oncogenic niche cells” ( ONC s) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONC s depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONC s identified in Drosophila and describes the genetic basis of non‐autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.