English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Obesity is a risk factor for colorectal cancer. The accumulation of abdominal fat tissue causes abundant reactive oxygen species production through the activation of  NADPH  oxidase due to excessive insulin stimulation. The enzyme  NADPH  oxidase catalyzes the production of reactive oxygen species and evokes the initiation and progression of tumorigenesis. Apocynin is an  NADPH  oxidase inhibitor that blocks the formation of the  NADPH  oxidase complex (active form). In this study, we investigated the effects of apocynin on the development of azoxymethane‐induced colonic aberrant crypt foci in obese  KK ‐ A  y  mice and on the development of intestinal polyps in  Apc  mutant Min mice. Six‐week‐old  KK ‐ A  y  mice were injected with azoxymethane (200 μg/mouse once per week for 3 weeks) and given 250 mg/L apocynin or 500 mg/L apocynin in their drinking water for 7 weeks. Six‐week‐old Min mice were also treated with 500 mg/L apocynin for 6 weeks. Treatment with apocynin reduced the number of colorectal aberrant crypt foci in  KK ‐ A   y   mice by 21% and the number of intestinal polyps in Min mice by 40% compared with untreated mice. Both groups of mice tended to show improved oxidation of serum low‐density lipoprotein and 8‐oxo‐2′‐deoxyguanosine adducts in their adipose tissues. In addition, the inducible nitric oxide synthase  mRNA  levels in polyp tissues decreased. Moreover, apocynin was shown to suppress nuclear factor‐κB transcriptional activity  in vitro . These results suggest that apocynin and other  NADPH  oxidase inhibitors may be effective colorectal cancer chemopreventive agents.

Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK ‐ A y and Apc mutant Min mice