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Hematopoietic pre‐B cell leukemia transcription factor interacting protein ( HPIP ) has been shown to play an important role in the development and progression of some cancers. However, the role of  HPIP  in gastric cancer ( GC ) is unclear. Here, we show that  HPIP  is upregulated in most  GC  patients and promotes  GC  cell proliferation, migration, and invasion. In  GC  patients,  HPIP  positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation. Hematopoietic pre‐B cell leukemia transcription factor interacting protein increases  GC  cell proliferation through activation of G 1 /S and G 2 /M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. Hematopoietic pre‐B cell leukemia transcription factor interacting protein enhances  GC  cell migration and invasion, and modulates epithelial–mesenchymal transition, which plays a key role in cancer cell migration and invasion. These data underscore the critical role of  HPIP  in  GC  cell proliferation and progression and suggest that  HPIP  inhibition may be a useful therapeutic strategy for  GC  treatment.

cancer science

Hematopoietic pre‐B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion