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Epithelial–mesenchymal transition ( EMT ) is an important mechanism of cancer invasion and metastasis. Although p53 binding protein 1 ( 53 BP 1 ) has been implicated in several biological processes, its function in  EMT  of human cancers has not yet been reported. Here, we show that  53 BP 1  negatively regulated  EMT  by modulating   ZEB 1  through targeting micro RNA  (miR)‐200b and miR‐429. Furthermore,  53 BP 1  promoted   ZEB 1 ‐mediated upregulation of E‐cadherin and also inhibited the expressions of mesenchymal markers, leading to increased migration and invasion in  MDA ‐ MB ‐231 breast cancer cells. Consistently, in  MCF ‐7 breast cancer cells, low  53 BP 1  expression reduced E‐cadherin expression, resulting in increased migration and invasion. These effects were reversed by miR‐200b and miR‐429 inhibition or overexpression. Sections of tumor xenograft model showed increased   ZEB 1  expression and decreased E‐cadherin expression with the downregulation of  53 BP 1 . In 18 clinical tissue samples, expression of  53 BP 1  was positively correlated with miR‐200b and mir‐429 and negatively correlated with   ZEB 1 . It was also found that  53 BP 1  was associated with lymph node metastasis. Taken together, these results suggest that  53 BP 1  functioned as a tumor suppressor gene by its novel negative control of  EMT  through regulating the expression of miR‐200b/429 and their target gene   ZEB 1 .

53 BP 1 suppresses epithelial–mesenchymal transition by downregulating ZEB 1 through micro RNA ‐200b/429 in breast cancer