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Our aim was to analyze the potential role of chemokine receptors  CXCR 2 and  CXCR 4 signalling pathways in liver metastatic colorectal cancer ( CRC ) relapse.  CXCR 2,  CXCR 4, and their chemokine ligands were evaluated in liver metastases of colorectal cancer in order to study their correlation with overall and disease‐free survival of patients having received, or not received, a neoadjuvant chemotherapy regimen. Quantitative  RT ‐ PCR  and  CXCR 2 immunohistochemical staining were carried out using  CRC  liver metastasis samples. Expression levels of  CXCR 2,  CXCR 4, and their ligands were statistically analyzed according to treatment with neoadjuvant chemotherapy and patients’ outcome.  CXCR 2 and  CXCL 7 overexpression are correlated to shorter overall and disease‐free survival. By multivariate analysis,  CXCR 2 and  CXCL 7 expressions are independent factors of overall and disease‐free survival. Neoadjuvant chemotherapy increases significantly the expression of  CXCR 2: treated group 1.89 (0.02–50.92)  vs  0.55 (0.07–3.22),  P  = 0.016.  CXCL 7 was overexpressed close to significance, 0.40 (0.00–7.85)  vs  0.15 (0.01–7.88),  P  = 0.12. We show the involvement of  CXCL 7/ CXCR 2 signalling pathways as a predictive factor of poor outcome in metastatic  CRC . 5‐Fluorouracil‐based chemotherapy regimens increase the expression of these genes in liver metastasis, providing one explanation for aggressiveness of relapsed drug‐resistant tumors. Selective blockage of  CXCR 2/ CXCL 7 signalling pathways could provide new potential therapeutic opportunities.

cancer science

Overexpression of chemokine receptor  CXCR 2 and ligand  CXCL 7 in liver metastases from colon cancer is correlated to shorter disease‐free and overall survival