Open AccessMicroparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type
Author(s) -
Souza Paloma Silva,
Cruz André L.S.,
Viola João P.B.,
Maia Raquel C.
Publication year - 2015
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12566
Subject(s) - cancer cell , multiple drug resistance , apoptosis , efflux , cancer , biology , cancer research , p glycoprotein , microrna , phenotype , drug resistance , cell , microbiology and biotechnology , gene , biochemistry , genetics
Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P‐glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins ( IAP ) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival. MDR molecules have been identified in membrane microparticles ( MP ) and can be transferred to sensitive cancer cells. By co‐culturing MP derived from MDR‐positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA . In addition, MP promoted microRNA transfer and NFκB and Yb‐1 activation. Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.