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Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P‐glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins ( IAP ) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival.  MDR  molecules have been identified in membrane microparticles ( MP ) and can be transferred to sensitive cancer cells. By co‐culturing MP derived from MDR‐positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and  mRNA . In addition, MP promoted microRNA transfer and NFκB and Yb‐1 activation. Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.

Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type