Open AccessSuprabasin as a novel tumor endothelial cell marker
Author(s) -
Alam Mohammad T.,
NagaoKitamoto Hiroko,
Ohga Noritaka,
Akiyama Kosuke,
Maishi Nako,
Kawamoto Taisuke,
Shinohara Nobuo,
Taketomi Akinobu,
Shindoh Masanobu,
Hida Yasuhiro,
Hida Kyoko
Publication year - 2014
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12549
Subject(s) - tec , downregulation and upregulation , cancer research , pten , biology , protein kinase b , stromal cell , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , gene , genetics , ionosphere , physics , astronomy
Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells ( TEC ) characteristics were different from those of normal endothelial cells ( NEC ). Furthermore, we performed gene profile analysis in TEC and NEC , revealing that suprabasin ( SBSN ) was upregulated in TEC compared with NEC . However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC . SBSN knockdown inhibited the migration and tube formation ability of TEC . We also showed that the AKT pathway was a downstream factor of SBSN . These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.