Open AccessSilencing of STRN 4 suppresses the malignant characteristics of cancer cells
Author(s) -
Wong Meihong,
Hyodo Toshinori,
Asano Eri,
Funasaka Kohei,
Miyahara Ryoji,
Hirooka Yoshiki,
Goto Hidemi,
Hamaguchi Michinari,
Senga Takeshi
Publication year - 2014
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12541
Subject(s) - gene silencing , cancer research , cancer , microbiology and biotechnology , cancer cell , chemistry , biology , genetics , biochemistry , gene
The striatin family of proteins, comprising STRN , STRN 3 and STRN 4, are multidomain‐containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN 4 directly associated with protein kinases, such as MINK 1, TNIK and MAP 4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN 4 is associated with tumor progression. In this report, we examined the role that STRN 4 plays in cancer malignancy. We show that depletion of STRN 4 suppresses proliferation, migration, invasion and the anchorage‐independent growth of cancer cells. In addition, STRN 4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN 4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN 4 in tumor progression.