Open AccessTumor mi R ‐125b predicts recurrence and survival of patients with clear‐cell renal cell carcinoma after surgical resection
Author(s) -
Fu Qiang,
Liu Zheng,
Pan Deng,
Zhang Weijuan,
Xu Le,
Zhu Yu,
Liu Haiou,
Xu Jiejie
Publication year - 2014
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12507
Subject(s) - medicine , renal cell carcinoma , nephrectomy , proportional hazards model , concordance , oncology , cohort , clear cell renal cell carcinoma , stage (stratigraphy) , nomogram , biomarker , kidney cancer , tnm staging system , survival analysis , cancer , kidney , neoplasm staging , chemistry , paleontology , biochemistry , biology
The present study aims to evaluate the impact of tumor micro RNA ‐125b (mi R ‐125b) on recurrence and survival of patients with clear‐cell renal cell carcinoma (cc RCC ) following surgery. We retrospectively enrolled 276 patients (200 in the training cohort and 76 in the validation cohort) with cc RCC undergoing nephrectomy at a single institution. Clinicopathologic features, cancer‐specific survival ( CSS ) and recurrence‐free survival ( RFS ) were recorded. Tumor mi R ‐125b levels were assessed by in situ hybridization ( ISH ) in specimens of patients. The Kaplan–Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on CSS and RFS . A concordance index ( C ‐index) was calculated to assess predictive accuracy. In both cohorts, tumor mi R ‐125b positively correlated with F uhrman grade. High tumor mi R ‐125b indicated poor survival and early recurrence for patients with cc RCC , especially with advanced stage disease. After multivariable adjustment, tumor mi R ‐125b was identified as an independent adverse prognostic factor for survival and recurrence. The predictive accuracy of traditional TNM and UCLA Integrated Staging System prognostic models was improved when tumor mi R ‐125b was added. The results showed that tumor mi R ‐125b is a potential independent adverse prognostic biomarker for recurrence and survival of patients with cc RCC after nephrectomy.