English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Thymus and activation‐regulated chemokine ( TARC ) can stimulate cancer cell proliferation and migration. The present study evaluated the clinical significance of serum  TARC  in gastric cancer ( GC ). We measured serum  TARC , macrophage‐derived chemokine, monocyte chemotactic protein‐1 and stem cell factor ( SCF ) levels using a chemiluminescent immunoassay along the  GC  carcinogenesis (normal, high‐risk, early  GC  [ EGC ] and advanced  GC  [ AGC ]) in both training ( N  = 25 per group) and independent validation datasets (90 normal, 30 high‐risk, 50  EGC  and 50  AGC ). Serum levels were compared among groups using one‐way analysis of variance. To evaluate the diagnostic potential of serum  TARC  for  GC , receiver operating characteristic curve and logistic regression analyses were performed. Correlations between serum  TARC  and  GC  clinicopathological features were analyzed using Spearman's correlation. In the training dataset, serum  TARC  correlated with serum  MDC ,  MCP ‐1 and  SCF . However, only serum  TARC  and  SCF  were significantly higher in cancer groups than non‐cancer groups ( P  < 0.001). In the validation dataset, serum  TARC  also increased along the GC carcinogenesis; the  AGC  group (167.2 ± 111.1 ng/mL) had significantly higher levels than the  EGC  (109.1 ± 67.7 ng/mL), the high‐risk (66.2 ± 47.7 ng/mL) and the normal (67.5 ± 36.2 ng/mL) groups (Bonferroni, all  P  < 0.001). Receiver operating characteristic curves and logistic regression demonstrated the remarkable diagnostic potential of serum TARC as a single marker (72.0% sensitivity and 71.1% specificity; cutoff point, 0.37; logistic regression) and in a multiple‐marker panel (72.6% sensitivity and 88.2% specificity; cutoff point, 0.54). Spearman's correlation showed that serum TARC was closely correlated with tumor size (γ  s   = 0.227,  P =  0.028), T‐stage (γ  s   = 0.340,  P =  0.001), N‐stage (γ  s   = 0.318,  P =  0.002) and M‐stage (γ  s   = 0.346,  P =  0.001). Serum TARC is a promising serum biomarker for GC.

Clinical significance of serum thymus and activation‐regulated chemokine in gastric cancer: Potential as a serum biomarker