English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The lymphatic system plays important roles not only in the physiological processes, such as maintenance of tissue fluid homeostasis, but also in pathological processes including the lymph node metastasis of tumor cells. Therefore, understanding of the molecular mechanisms underlying lymphatic vessel formation is crucial. Previous studies have shown that proliferation and migration of lymphatic endothelial cells ( LEC s) are activated by multiple types of signals mediated by tyrosine kinase receptors such as vascular endothelial growth factor receptor ( VEGFR ) 3. Although signals mediated by platelet‐derived growth factor receptor β ( PDGFR β) have been implicated in lymphangiogenesis, the mechanisms explaining how  PDGFR β expression is maintained in  LEC s remain to be fully elucidated. In the present study, we show that  PDGFR β expression in  LEC s is maintained by Prox1 transcription factor. Knockdown of Prox1 expression in human dermal  LEC s decreased the expression of  PDGFR β, leading to the lowered migration of human dermal  LEC s towards  PDGF ‐ BB . Furthermore, we found that  PDGF  signals play important roles in inflammatory lymphangiogenesis in a chronic aseptic peritonitis model. Intraperitoneal administration of imatinib, a potent inhibitor of  PDGFR β, and transduction of  PDGFR β/Fc chimeric protein by an adenoviral system both reduced inflammatory lymphangiogenesis induced by thioglycollate in mice. We also found that the expression of  PDGFR β/Fc reduced tumor lymphangiogenesis in a Bx PC 3 human pancreatic cancer xenograft model. These findings suggest that  PDGFR β is one of the key mediators of lymphatic vessel formation acting downstream of Prox1.

cancer science

Expression of platelet‐derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis