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Our recent studies of the micro RNA  (mi RNA ) expression signature in prostate cancer ( PC a) indicated that  mi RNA ‐218  ( miR‐218 ) was significantly downregulated in clinical specimens, suggesting that  miR‐218  might act as a tumor‐suppressive mi RNA  in  PC a. The aim of the present study was to investigate the functional significance of  miR‐218  in  PC a and to identify novel  miR‐218 ‐regulated cancer pathways and target genes involved in  PC a oncogenesis and metastasis. Restoration of  miR‐218  in  PC a cell lines ( PC 3 and  DU 145) revealed that this mi RNA  significantly inhibited cancer cell migration and invasion. Gene expression data and  in silico  analysis demonstrated that  LIM  and  SH 3 protein 1 ( LASP 1) is a potential target of  miR‐218  regulation.  LASP 1 is a cytoskeletal scaffold protein that plays critical roles in cytoskeletal organization and cell migration. Luciferase reporter assays showed that  miR‐218  directly regulated expression of   LASP 1 . Moreover, downregulating the   LASP 1  gene significantly inhibited cell migration and invasion in cancer cells, and the expression of  LASP 1 was upregulated in cancer tissues. We conclude that loss of tumor‐suppressive  miR‐218  enhanced cancer cell migration and invasion in  PC a through direct regulation of   LASP 1 . Our data on pathways regulated by tumor‐suppressive  miR‐218  provide new insight into the potential mechanisms of  PC a oncogenesis and metastasis.

Tumor‐suppressive micro RNA ‐218 inhibits cancer cell migration and invasion via targeting of LASP 1 in prostate cancer