Open AccessIncidence of multiple primary cancers and interval between first and second primary cancers
Author(s) -
Utada Mai,
Ohno Yuko,
Hori Megumi,
Soda Midori
Publication year - 2014
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12433
Subject(s) - medicine , cancer , primary cancer , incidence (geometry) , cancer registry , confidence interval , population , relative risk , retrospective cohort study , oncology , gynecology , environmental health , physics , optics
In this retrospective study, we aimed to clarify the risk of developing a second primary cancer and to determine the periods of high risk of second primary cancers. Subjects were all patients who had been diagnosed with a first primary cancer and registered with the N agasaki P refecture C ancer R egistry between 1985 and 2007. We calculated the standardized incidence ratio ( SIR ) of second primary cancer according to site and years after diagnosis of the first primary cancer. A second primary cancer developed in 14 167 of 174 477 subjects (8.1%) during a median follow‐up of 1.8 years. The SIR of all cancer was 1.10 (95% confidence interval, 1.08–1.11). Some specific relationships were observed between sites with risk factors in common, such as smoking, drinking, and hormone status. The SIR s were relatively high after approximately 10 years for all sites, and trends differ among cancer sites. We showed that cancer patients are at higher risk of a second primary cancer than the general population. In respect of the risk of a second primary cancer, physicians should be alert for cancers that have risk factors in common with the first primary cancer.