English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

BACH 2, a B cell‐specific transcriptional repressor, plays a significant role in B cell maturation. Despite a number of previous studies, the clinicopathological significance of  BACH 2 expression in diffuse large B cell lymphoma ( DLBCL ) remains to be established. The present study was performed to validate the significance of  BACH 2 expression as a predictor of prognosis in  DLBCL . A total of 94  DLBCL  cases were included in the present study. All were diagnosed between 2008 and 2011, and thorough clinical and pathological investigations were possible, including immunohistochemical analysis of  BACH 2. Eighteen cases were selected by positive  MYC  gene alteration ( MYC + group) according to cytogenetic study. The remaining 76 cases were subclassified into germinal center B cell phenotype ( GCB  group, 38 cases) or non‐ GCB  phenotype (non‐ GCB  group, 38 cases). There were no significant differences between the two groups with regard to clinical characteristics and outcomes. In the  GCB  group, 21 cases were judged to have high  BACH 2 expression, with 19 cases in the non‐ GCB  group. In cases with high  BACH 2 expression in  GCB  and non‐ GCB  groups, the 3‐year overall survival ( OS ) rate was significantly shorter than that with low expression (71.7%  vs  91.3%,  P  = 0.0256). In the  MYC + group, 15 cases had high  BACH 2 expression levels. Although overall the  MYC + group showed short survival time (3‐year  OS  35.0%), 3 out of 4 cases with low  BACH 2 expression are alive without disease relapse at the time of publication of this paper. In conclusion,  BACH 2 expression level is a promising predictor of prognosis for  DLBCL .

Association between BACH 2 expression and clinical prognosis in diffuse large B‐cell lymphoma