English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Large granular lymphocyte leukemia ( LGL  L) has been morphologically characterized as a group of lymphoproliferative diseases that include T‐cell large granular lymphocytic leukemia (T‐ LGL  L) and chronic lymphoproliferative disorders of natural killer cells ( CLPD ‐ NK ). We investigated mutations in the Src homology 2 ( SH 2) domain of the  signal transducer and activator of transcription 3 ( STAT 3)  gene in Asian cohorts of T‐ LGL  L and  CLPD ‐ NK  ( n  = 42 and 11, respectively). Two mutations, Y640F and D661Y, were identified using direct sequencing or allele‐specific ( AS )  PCR . Y640F and D661Y mutations were found in seven and 18 patients, respectively. Two patients were positive for both mutations. Frequencies of  STAT3  mutations in T‐ LGL  L and  CLPD ‐ NK  were 47.6% and 27.2%, respectively. Pure red cell aplasia ( PRCA ) was associated with the mutations ( P  = 0.005). The mutations were persistently found at stable levels in some patients after more than 5 years using  AS ‐quantitative  PCR . The results of the present study indicate that the  SH 2 domain of the  STAT3  gene is frequently mutated in Asian T‐ LGL  L and  CLPD ‐ NK , and that  PRCA  is closely correlated with the mutations.

STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia