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The epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of human cancers and is associated with patient prognosis, including those with lung cancer. However, the association of single nucleotide polymorphisms (SNPs) in the  EpCAM  gene with the prognosis for non‐small‐cell lung cancer ( NSCLC ) patients has never been investigated. We evaluated the association between two  SNP s, rs1126497 and rs1421, in the  EpCAM  gene and clinical outcomes in a Chinese cohort of 506  NSCLC  patients. The SNPs were genotyped using the Sequenom  iPLEX  genotyping system. Multivariate Cox proportional hazards model and Kaplan–Meier curves were used to assess the association of  EpCAM  gene genotypes with the prognosis of  NSCLC . We found that the non‐synonymous  SNP  rs1126497 was significantly associated with survival. Compared with the  CC  genotype, the  CT + TT  genotype was a risk factor for both death (hazard ratio, 1.40; 95% confidence interval [CI], 1.02–1.94;  P  = 0.040) and recurrence (hazard ratio, 1.34; 95% CI, 1.02–1.77;  P  = 0.039). However, the  SNP  rs1421 did not show any significant effect on patient prognosis. Instead, the  AG+GG  genotype in rs1421 was significantly associated with early T stages (T1/T2) when compared with the  AA  genotype (odds ratio for late stage = 0.65; 95% CI, 0.44–0.96,  P  = 0.029). Further stratified analysis showed notable modulating effects of clinical characteristics on the associations between variant genotypes of rs1126497 and NSCLC outcomes. In conclusion, our study indicated that the non‐synonymous SNP rs1126497 may be a potential prognostic marker for  NSCLC  patients.

Polymorphisms of Ep CAM gene and prognosis for non‐small‐cell lung cancer in Han C hinese