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Osteosarcoma mechanobiology and therapeutic targets
Author(s) -
Shoaib Zunaira,
Fan Timothy M.,
Irudayaraj Joseph M. K.
Publication year - 2022
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15713
Subject(s) - mechanobiology , mechanosensitive channels , osteosarcoma , medicine , tumor microenvironment , cancer research , pathology , bioinformatics , biology , anatomy , tumor cells , receptor , ion channel
Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remodelling. Osteosarcoma prognosis is location dependent, which further emphasizes the likely contribution of the bone microenvironment in its pathogenesis. Mechanobiology describes the processes involved when mechanical cues from the changing physical microenvironment of the bone are transduced to biological pathways through mechanosensitive cellular components. Mechanobiology‐driven therapies have been used to curb tumour progression by direct alteration of the physical microenvironment or inhibition of metastasis‐associated mechanosensitive proteins. This review emphasizes the contribution of mechanobiology to the progression of osteosarcoma and sheds light on current mechanobiology‐based therapies and potential new targets for improving disease management. Additionally, the many different 3D models currently used to study osteosarcoma mechanobiology are summarized.