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Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice
Author(s) -
Augestad Ingrid Lovise,
Dekens Doortje,
Karampatsi Dimitra,
Elabi Osama,
Zabala Alexander,
Pintana Hiranya,
Larsson Martin,
Nyström Thomas,
Paul Gesine,
Darsalia Vladimer,
Patrone Cesare
Publication year - 2022
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15524
Subject(s) - medicine , endocrinology , stroke (engine) , atrophy , diabetes mellitus , neurogenesis , neuroinflammation , biology , inflammation , neuroscience , mechanical engineering , engineering
Glucagon-like peptide-1 (GLP-1) receptor activation decreases stroke risk in people with Type 2 diabetes (T2D), while animal studies have shown the efficacy of this strategy to counteract stroke-induced acute brain damage. However, whether GLP-1 receptor activation also improves recovery in the chronic phase after stroke is unknown. We investigated whether post-acute, chronic administration of the GLP-1 receptor agonist, exendin-4, improves post-stroke recovery and examined possible underlying mechanisms in T2D and non-T2D mice.