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Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
Author(s) -
DoñateMacian Pablo,
Duarte Yorley,
RubioMoscardo Fanny,
PérezVilaró Gemma,
Canan Jonathan,
Díez Juana,
GonzálezNilo Fernando,
Valverde Miguel A.
Publication year - 2022
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15267
Subject(s) - in silico , trpv4 , transient receptor potential channel , chemistry , virtual screening , docking (animal) , computational biology , structure–activity relationship , drug discovery , binding site , pharmacology , biophysics , biochemistry , biology , receptor , in vitro , medicine , nursing , gene
The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting pharmacological target with therapeutic potential. However, little is known about the structural elements governing its inhibition.