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Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop
Author(s) -
Held Katharina,
Aloi Vincenzo Davide,
Freitas Ana Cristiogueira,
Janssens Annelies,
Segal Andrei,
Przibilla Julia,
Philipp Stephan Ernst,
Wang Yu Tian,
Voets Thomas,
Vriens Joris
Publication year - 2022
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.15223
Subject(s) - biophysics , transient receptor potential channel , gating , chemistry , alternative splicing , gene isoform , mutagenesis , receptor , mutant , biochemistry , biology , gene
Transient receptor potential melastatin 3 (TRPM3) is a non-selective cation channel that plays a pivotal role in the peripheral nervous system as a transducer of painful heat signals. Alternative splicing gives rise to several TRPM3 variants. The functional consequences of these splice isoforms are poorly understood. Here, the pharmacological properties of TRPM3 variants arising from alternative splicing in the pore-forming region were compared.