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Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the H ippo signalling pathway
Author(s) -
Zhao WeiBo,
Lu Qun,
Nguyen MyNhan,
Su Yidan,
Ziemann Mark,
Wang LiNa,
Kiriazis Helen,
Puthalakath Hamsa,
Sadoshima Junichi,
Hu HouYuan,
Du XiaoJun
Publication year - 2019
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14674
Subject(s) - isoprenaline , phosphorylation , microbiology and biotechnology , gene knockdown , agonist , kinase , galectin 3 , genetically modified mouse , biology , transgene , stimulation , protein kinase a , galectin , receptor , endocrinology , apoptosis , immunology , biochemistry , gene
Expression of the pro-fibrotic galectin-3 and the pro-apoptotic BIM is elevated in diseased heart or after β-adrenoceptor stimulation, but the underlying mechanisms are unclear. This question was addressed in the present study.