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Restoration of perivascular adipose tissue function in diet‐induced obese mice without changing bodyweight
Author(s) -
Xia Ning,
Weisenburger Sabrina,
Koch Egon,
Burkart Martin,
Reifenberg Gisela,
Förstermann Ulrich,
Li Huige
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13703
Subject(s) - enos , adipose tissue , endocrinology , medicine , endothelial dysfunction , vasodilation , obesity , aorta , diet induced obese , thoracic aorta , nitric oxide , chemistry , insulin resistance , nitric oxide synthase
We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity-induced vascular dysfunction in mice. The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity.