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Prolonged morphine treatment alters δ opioid receptor post‐internalization trafficking
Author(s) -
Ong E W,
Xue L,
Olmstead M C,
Cahill C M
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12761
Subject(s) - internalization , damgo , agonist , receptor , opioid receptor , pharmacology , μ opioid receptor , chemistry , opioid , microbiology and biotechnology , endocrinology , biology , biochemistry
The δ opioid receptor (DOP receptor) undergoes internalization both constitutively and in response to agonists. Previous work has shown that DOP receptors traffic from intracellular compartments to neuronal cell membranes following prolonged morphine treatment. Here, we examined the effects of prolonged morphine treatment on the post-internalization trafficking of DOP receptors.