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Activation of the δ‐opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration
Author(s) -
Bigliardi P L,
Neumann C,
Teo Y L,
Pant A,
BigliardiQi M
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12687
Subject(s) - microbiology and biotechnology , receptor , opioid receptor , receptor expression , wound healing , cell migration , keratinocyte , chemistry , cell adhesion , biology , opioid , immunology , cell , in vitro , biochemistry
In addition to its analgesic functions, the peripheral opioid receptor system affects skin homeostasis by influencing cell differentiation, migration and adhesion; also, wound healing is altered in δ-opioid receptor knockout mice (DOPr(-/-) ). Hence, we investigated δ-opioid receptor effects on the expression of several proteins of the desmosomal junction complex and on the migratory behaviour of keratinocytes.