z-logo
open-access-imgOpen Access
Experimental Models of Neuromyelitis Optica
Author(s) -
Bradl Monika,
Lassmann Hans
Publication year - 2014
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12098
Subject(s) - neuromyelitis optica , multiple sclerosis , autoantibody , aquaporin 4 , neuroscience , medicine , central nervous system , demyelinating disorder , water channel , immunology , antibody , pathology , biology , mechanical engineering , engineering , inlet
For a long time, the most important inflammatory demyelinating diseases of the central nervous system ( CNS ), for example, multiple sclerosis ( MS ) and neuromyelitis optica ( NMO ), were extremely hard to differentiate, often with severe consequences for affected patients. This changed with the discovery of NMO ‐immunoglobulin G ( IgG ), a specific autoantibody which was detected in the vast majority of NMO patients, and with the demonstration that this autoantibody targets aquaporin 4 ( AQP 4), a water channel found on astrocytes in the CNS . These findings paved the way for the generation of experimental models of NMO . This chapter will discuss the contribution of experimental models to NMO research and what key questions remain to be addressed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here