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Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease
Author(s) -
Blok Joost M.,
Kerst J. Martijn,
Vegt Erik,
Brouwer Oscar R.,
Meijer Richard P.,
Bosch J.L.H. Ruud,
Bex Axel,
Poel Henk G.,
Horenblas Simon
Publication year - 2019
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.14618
Subject(s) - medicine , occult , sentinel node , stage (stratigraphy) , radiology , malignancy , biopsy , testicular cancer , orchiectomy , localized disease , cancer , surgery , prostate cancer , pathology , breast cancer , paleontology , alternative medicine , biology
Objectives To report the long‐term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility. Patients and Methods We conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated with an SN procedure at our tertiary referral centre. SNs were identified using lymphoscintigraphy with or without single‐photo‐emission computed tomography with CT (SPECT/CT). Patients underwent laparoscopic retroperitoneal SN excision with inguinal orchiectomy. Patients with a tumour‐positive SN underwent adjuvant treatment. Follow‐up was conducted according to then‐current guidelines. Results In two patients, no SNs were visualized on scintigraphy. In the remaining 25 patients, a median (range) of 3 (1–4) SNs per patient were removed. Two patients showed no malignancy on histopathological examination of the testis. Of the 23 patients diagnosed with TGCT (16 seminomas, seven non‐seminomas), three (13.0%) had occult metastatic disease. All 23 patients were without evidence of disease at a median (range) follow‐up of 63.9 (29.0–143.4) months. Conclusion The SN procedure allows early identification of patients with occult metastatic disease in clinical stage I TGCT, enabling early treatment.