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Developing role of B cells in the pathogenesis and treatment of chronic GVHD
Author(s) -
Li Xiaoping,
Gao Qiangguo,
Feng Yimei,
Zhang Xi
Publication year - 2019
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.15719
Subject(s) - pathogenesis , graft versus host disease , immunology , hematopoietic stem cell transplantation , stem cell , disease , b cell , medicine , autoantibody , haematopoiesis , transplantation , biology , cancer research , pathology , antibody , microbiology and biotechnology
Summary Chronic graft‐versus‐host disease (cGVHD) is a major complication affecting the long‐term survival of patients after allogeneic haematopoietic stem cell transplantation. The mechanism of cGVHD is unclear, and while previous studies have primarily focused on T cells, the role of B cells in the pathogenesis of cGVHD has been less reported. However, current studies on cGVHD are increasingly focused on the important role of B cells. In this review, we will introduce the newest studies and examine the role of B cells in cGVHD in detail with respect to the following aspects: altered B cell subpopulations, aberrant B cell signalling pathways, autoantibodies and T‐B cell interactions. Treatment strategies for the targeting of B cells during cGVHD will also be discussed.