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Summary  This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well‐documented patients with chronic lymphocytic leukaemia. The duration of both time to first treatment ( TTFT ) and overall survival ( OS ) were significantly longer than observed previously, and this is at least partly due to improved therapeutic options. Deletion 13q remains the most favourable prognostic group with median  TTFT  and  OS  from fluorescence  in situ  hybridization ( FISH ) testing of 72 months and >12 years, respectively. Deletion 11q had the poorest median  TTFT  (22 months) and 17p deletion the poorest median  OS  (5 years). The percentages of abnormal nuclei were significantly associated with differential  TTFT  for the trisomy 12, 13q and 17p deletion cohorts but not for the 11q deletion cohort. From the date of the first  FISH  study, patients with >85% 13q deletion nuclei had a notably shorter  TTFT  (24 months). Patients with ≤20% 17p deletion nuclei had longer median  TTFT  and  OS  from the date of the first  FISH  study (44 months and 11 years), and were more likely to be   IGHV   mutated.

british journal of haematology

The Dohner fluorescence  in situ  hybridization prognostic classification of chronic lymphocytic leukaemia ( CLL ): the  CLL  Research Consortium experience