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Summary   Clinical scenario  A 65‐year‐old man presented with a 12‐h history of deteriorating rash. Two weeks previously he had completed a course of neoadjuvant chemotherapy for ductal carcinoma of the breast. On examination there were bullae, widespread atypical targetoid lesions and 15% epidermal detachment. There was no mucosal involvement on presentation, but subsequently it did evolve. Skin biopsy showed subepidermal blistering with epidermal necrosis. This confirmed our clinical diagnosis of overlap Stevens–Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ). On transfer to intensive care he was anxious and fearful.    Management question  What are the psychological impacts of SJS/TEN on this man's life?    Background   SJS  and  TEN  have devastating outcomes for those affected.    Objectives  To conduct a Critically Appraised Topic to (i) analyse existing research related to the psychological impact of  SJS  and  TEN  and (ii) apply the results to the clinical scenario.    Methods  Seven electronic databases were searched for publications focusing on the psychological impact of  SJS / TEN  on adults over 18 years of age.    Results  Six studies met the inclusion criteria. Healthcare practitioners’ ( HCP s’) lack of information around the disorder was highlighted. Patients experienced undue stress and fear. Some patients had symptoms aligned to post‐traumatic stress disorder ( PTSD ), anxiety and depression.    Discussion and recommendation  The evidence suggests that  SJS  and  TEN  impact psychologically on patients’ lives. Education of  HCP s, to address their lack of awareness and information on  SJS / TEN , should facilitate their capacity to provide information and support to patients, thereby reducing patient anxiety. On discharge, a follow‐up appointment with relevant  HCP s to reduce the possibility of  PTSD  occurring should be considered.

The psychological impact of Stevens–Johnson syndrome and toxic epidermal necrolysis on patients’ lives: a Critically Appraised Topic *