English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Summary   Background  Better understanding of the relationship between atopic dermatitis ( AD ) severity and health‐related quality of life ( HRQ oL) could help improve knowledge of a more effective treatment for people with  AD .    Objectives  To assess the relationship between  AD  severity and  HRQ oL and perception of  AD  symptoms in adults with moderate‐to‐severe  AD  in Europe and the U.S.A.    Methods  Participants for this cross‐sectional, internet‐based survey were recruited from the larger population‐based National Health and Wellness Survey.  AD  severity was measured by Patient‐Oriented  SCOR ing of  AD .  HRQ oL was measured by the five‐level EuroQol‐5D, Dermatology Life Quality Index ( DLQI ) and Patient‐Oriented Eczema Measure ( POEM ).    Results  Altogether, 1232 respondents were included: 1098 (89·1%) with moderate‐to‐severe  AD  [221 (20·1%) from France, 209 (19·0%) from Germany, 118 (10·7%) from the U.K. and 550 (50·1%) from the U.S.A.]. An additional 134 (10·9%) respondents with mild  AD  were included. Sociodemographic and clinical  AD  characteristics were similar between countries. In adults with moderate‐to‐severe  AD , higher  AD  severity correlated with poorer  HRQ oL (Spearman's  r  = –0·38 and 0·61 for  EQ ‐5D and  DLQI , respectively; both  P  < 0·001).  AD  severity was positively correlated with  POEM  (Spearman's  r  = 0·51;  P  < 0·001). People with moderate‐to‐severe vs. those with mild  AD  had poorer health outcomes ( EQ ‐5D,  DLQI  and  POEM ,  P  < 0·001 for all). These results were similar and consistent for the European and the U.S. populations separately.    Conclusions  Higher  AD  severity is associated with poorer  HRQ oL across Europe and the U.S.A. This is a burden for patients and may provide encouragement for more effective management of  AD .What's already known about this topic?Atopic dermatitis (AD) is associated with a detrimental effect on health‐related quality of life (HRQoL), including sleep disturbance, anxiety and depression.  Limited data describing the relationship between different levels of AD severity and self‐reported HRQoL have been published.What does this study add?There is a positive association between increasing AD severity (Patient‐Oriented SCORing of AD) and decreasing HRQoL (EQ‐5D and Dermatology Life Quality Index) and the perception of AD symptoms (Patient‐Oriented Eczema Measure) from the patient's perspective.  AD severity according to geographic locations was explored (France, Germany, the U.K., and the U.S.A.), showing that the decreasing HRQoL associated with increasing AD severity was quite consistent between the geographic locations.What are the clinical implications of this work?The results of this study showed that higher AD severity is associated with poorer HRQoL from the subject’s perspective in both Europe and the US. This fact confirms that there is a burden for these patients and may provide encouragement for a more effective management of AD, especially among those with greater AD severity.

british journal of dermatology

Higher self‐reported severity of atopic dermatitis in adults is associated with poorer self‐reported health‐related quality of life in France, Germany, the U.K. and the U.S.A.