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Summary   Background  Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second‐generation H 1 ‐antihistamine in the morning and a sedating first‐generation H 1 ‐antihistamine, usually hydroxyzine, at night to enhance sleep. But is this belief well founded?    Objectives  To test this belief by comparing the effectiveness and prevalence of unwanted sedative effects when treating patients with chronic spontaneous urticaria ( CSU ) with levocetirizine 15 mg daily plus hydroxyzine 50 mg at night (levocetirizine plus hydroxyzine) vs. levocetirizine 20 mg daily (levocetirizine monotherapy).    Methods  In this randomized, double‐blind, cross‐over study, 24 patients with difficult‐to‐treat  CSU  took levocetirizine plus hydroxyzine or levocetirizine monotherapy for periods of 5 days each. At the end of each treatment period, assessments were made of quality of life (Chronic Urticaria Quality of Life Questionnaire,  CU ‐Q 2 oL), severity of urticaria symptoms (Urticaria Activity Score,  UAS ), sleep disturbance during the night and daytime somnolence.    Results  Both treatments significantly decreased  UAS , night‐time sleep disturbances and  CU ‐Q 2 oL scores ( P  <   0·001) without significant differences between the two. Compared with baseline, daytime somnolence was significantly reduced by levocetirizine monotherapy ( P  = 0·006) but not by levocetirizine plus hydroxyzine ( P  =   0·218). Direct comparison of the two treatment modalities in terms of daytime somnolence favoured levocetirizine monotherapy ( P  = 0·026).    Conclusions  The widespread belief that sleep is aided by the addition of a sedating first‐generation H 1 ‐antihistamine, usually hydroxyzine, at night is not supported. These results are in line with the urticaria guidelines, which state that first‐line treatment for urticaria should be new‐generation, nonsedating H 1 ‐antihistamines only.

british journal of dermatology

Night‐time sedating H 1 ‐antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial