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Objectives  Cognitive reactivity ( CR ) to sad mood is a risk factor for major depressive disorder ( MDD ).  CR  is usually measured by assessing change on the Dysfunctional Attitudes Scale ( DAS ‐change) after sad mood‐induction. It has, however, been suggested that the versions of the  DAS  (A/B) are not interchangeable, impacting the reliability and validity of the change score. The Leiden Index of Depression Sensitivity‐Revised ( LEIDS ‐R) is an alternative self‐report measure of  CR . Studies examining the relationship between  LEIDS ‐R and  DAS ‐change have shown mixed results. We examined whether scores of these  CR  measures differed between remitted  MDD  and controls, the relationship between these  CR  measures, and the effect of order of  DAS  administration on  DAS ‐change.    Design  Cross‐sectional design with two groups (remitted  MDD  and controls).    Methods  Sixty‐eight  MDD  patients remitted from ≥2 previous episodes, not taking antidepressants, and 43 never‐depressed controls participated in a mood‐induction and filled in the  DAS ‐A/B in randomized order before and after mood‐induction, and  LEIDS ‐R separately.    Results   LEIDS ‐R scores and pre‐mood‐induction  DAS  scores were significantly higher in remitted  MDD  than controls ( p  < .001, Cohen's  d  =   1.48;  p  = .001, Cohen's  d  =   0.66, respectively).  DAS ‐change did not differ between these groups ( p  = .67, Cohen’ s d  =   0.08).  LEIDS ‐R correlated with  DAS ‐change ( r  = .30,  p  = .042), but only in the group that filled in  DAS ‐B before  DAS ‐A. In remitted  MDD ,  DAS ‐change was dependent on the order of  DAS  versions before and after mood‐induction (10.6 ± 19.0 vs. −1.2 ± 10.5, for order B‐A and A‐B, respectively), with a significant group × order interaction ( p  = .012).    Conclusions  Existing  DAS  versions are not interchangeable, which compromises the usefulness of mood‐inductions in clinical practice. The  LEIDS ‐R seems a valid measure of cognitive vulnerability to depression.    Practitioner points   Clinical implications:Cognitive reactivity ( CR ) is a risk factor of depressive recurrence. The current measurement of  CR , by assessing change on the Dysfunctional Attitudes Scale ( DAS ) after mood‐induction, is not reliable.  The Leiden Index Depression Sensitivity‐Revised ( LEIDS ‐R) is an alternative  CR  measure. In contrast to mood‐induction, it reliably assesses depression vulnerability.  The use of mood‐inductions for clinical/research purposes is unnecessary.Limitations of the study:We were not able to examine the effect of previous treatment, which could have affected results as psychological treatments probably have differential effects on  CR .  Examining un‐medicated patients may have led to selection of a sample not completely representative for the general  MDD  population.  We did not administer both parallel versions of the  DAS  (A/B) before and after mood‐induction. This might have provided better understanding of their differential sensitivity to change.

The measurement of cognitive reactivity to sad mood in patients remitted from major depressive disorder