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Objectives  The discovery of the blue lightsensitive retinal photoreceptor responsible for signaling daytime to the brain suggested that light to the circadian system could be inhibited by using blue‐blocking orange tinted glasses. Blue‐blocking ( BB ) glasses are a potential treatment option for bipolar mania. We examined the effectiveness of  BB  glasses in hospitalized patients with bipolar disorder in a manic state.    Methods  In a single‐blinded, randomized, placebo‐controlled trial ( RCT ), eligible patients (with bipolar mania; age 18–70 years) were recruited from five clinics in Norway. Patients were assigned to  BB  glasses or placebo (clear glasses) from 6 p.m. to 8 a.m. for 7 days, in addition to treatment as usual. Symptoms were assessed daily by use of the Young Mania Rating Scale ( YMRS ). Motor activity was assessed by actigraphy, and compared to data from a healthy control group. Wearing glasses for one evening/night qualified for inclusion in the intention‐to‐treat analysis.    Results  From February 2012 to February 2015, 32 patients were enrolled. Eight patients dropped out and one was excluded, resulting in 12 patients in the  BB  group and 11 patients in the placebo group. The mean decline in  YMRS  score was 14.1 [95% confidence interval ( CI ): 9.7–18.5] in the  BB  group, and 1.7 (95%  CI : −4.0 to 7.4) in the placebo group, yielding an effect size of 1.86 (Cohen's  d ). In the  BB  group, one patient reported headache and two patients experienced easily reversible depressive symptoms.    Conclusions  This  RCT  shows that  BB  glasses are effective and feasible as add‐on treatment for bipolar mania.

Blue‐blocking glasses as additive treatment for mania: a randomized placebo‐controlled trial