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Population Pharmacokinetic Meta‐Analysis of Vortioxetine in Healthy Individuals
Author(s) -
Areberg Johan,
Petersen Kamilla B.,
Chen Grace,
Naik Himanshu
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12256
Subject(s) - vortioxetine , pharmacokinetics , population pharmacokinetics , medicine , meta analysis , population , pharmacology , psychiatry , major depressive disorder , environmental health , cognition
The objective was to describe the pharmacokinetics of vortioxetine and evaluate the effect of intrinsic and extrinsic factors in the healthy population. Data from 26 clinical pharmacology studies were pooled. A total of 21,758 vortioxetine quantifiable plasma concentrations were collected from 887 subjects with corresponding demography. The doses ranged from 2.5 to 75 mg (single dose) and 2.5–60 mg (multiple QD doses). The pharmacokinetics of vortioxetine was best characterised by a two‐compartment model with first‐order absorption, lag‐time and linear elimination, with interindividual error terms for absorption rate constant, oral clearance and central volume of distribution. The population mean was 32.7 L/hr for oral clearance and 1.97∙10 3 L for the central volume of distribution. The average elimination half‐life was 65.8 hr. CYP 2D6 inferred metabolic status (ultra, extensive, intermediate or poor metabolisers) and age on oral clearance and height on central volume of distribution were identified as statistically significant covariate–parameter relationships. For CYP 2D6 poor metabolisers, CL /F was approximately 50% to that seen in CYP 2D6 extensive metabolisers. The impact of height on V 2/ F and age on CL /F was low and not considered to be clinically relevant. The final model was found to be reliable, stable and predictive. A reliable, stable and predictive pharmacokinetic model was developed to characterise pharmacokinetics of vortioxetine in the healthy population.