English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims  To estimate the 3 month prevalence of adverse drug events ( ADEs ), categories of  ADEs  and preventable  ADEs , and the preventability of  ADEs  among adults in  S weden. Further, to identify drug classes and organ systems associated with  ADEs  and estimate their seriousness.    Methods  A random sample of 5025 adults in a  S wedish county council in 2008 was drawn from the  T otal  P opulation  R egister. All their medical records in 29 inpatient care departments in three hospitals, 110 specialized outpatient clinics and 51 primary care units were reviewed retrospectively in a stepwise manner, and complemented with register data on dispensed drugs.  ADEs , including adverse drug reactions ( ADRs ), sub‐therapeutic effects of drug therapy ( STEs ), drug dependence and abuse, drug intoxications from overdose, and morbidities due to drug‐related untreated indication, were detected during a 3 month study period, and assessed for preventability.    Results  Among 4970 included individuals, the prevalence of  ADEs  was 12.0% (95% confidence interval (CI) 11.1, 12.9%), and preventable  ADEs  5.6% (95% CI 5.0, 6.2%).  ADRs  (6.9%; 95% CI 6.2, 7.6%) and  STEs  (6.4%; 95% CI 5.8, 7.1%) were more prevalent than the other  ADEs . Of the  ADEs , 38.8% (95% CI 35.8–41.9%) was preventable, varying by  ADE  category and seriousness.  ADEs  were frequently associated with nervous system and cardiovascular drugs, but the associated drugs and affected organs varied by  ADE  category.    Conclusions  The considerable burden of  ADEs  and preventable  ADEs  from commonly used drugs across care settings warrants large‐scale efforts to redesign safer, higher quality healthcare systems. The heterogeneous nature of the  ADE  categories should be considered in research and clinical practice for preventing, detecting and mitigating  ADEs .

Prevalence, nature and potential preventability of adverse drug events – a population‐based medical record study of 4970 adults