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Effects of melatonin on salsolinol‐induced prolactin secretion in goats
Author(s) -
Hashizume Tsutomu,
Yaegashi Tomoyoshi,
Jin Jin,
Sawai Ken,
Fülöp Ferenc,
Nagy György Miklos
Publication year - 2013
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/asj.12002
Subject(s) - sulpiride , prolactin , saline , melatonin , medicine , endocrinology , thyrotropin releasing hormone , antagonist , dopamine , basal (medicine) , chemistry , hormone , dopamine antagonist , receptor , insulin
Abstract The aim of the present study was to clarify the effect of melatonin ( MEL ) on the salsolinol ( SAL )‐induced release of prolactin ( PRL ) in goats. Female goats were kept at 20°C with 16 h of light, 8 h of darkness, and orally administered saline or MEL for 5 weeks. A single intravenous (i.v.) injection of saline (controls), SAL , thyrotropin‐releasing hormone ( TRH ) or a dopamine receptor antagonist, sulpiride, was given to the goats 3 weeks after the first oral administrations of saline or MEL , and the responses were compared. The mean basal plasma PRL concentrations in the control group were higher for the saline treatments than MEL treatments ( P < 0.05). SAL as well as TRH and sulpiride stimulated the release of PRL promptly after each injection in both the saline‐ and MEL ‐treated groups ( P < 0.05). The area under the response curve of PRL for the 60‐min period after the i.v. injection of SAL , TRH and sulpiride in the saline‐treated group was greater than each corresponding value in the MEL ‐treated group ( P < 0.05). These results show that daily exposure to MEL under a long day length reduces the PRL ‐releasing response to SAL as well as TRH and sulpiride in goats.