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A randomised controlled trial of an automated oxygen delivery algorithm for preterm neonates receiving supplemental oxygen without mechanical ventilation
Author(s) -
Zapata James,
Gómez John Jairo,
Araque Campo Robinson,
Matiz Rubio Alejandro,
Sola Augusto
Publication year - 2014
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12684
Subject(s) - medicine , fraction of inspired oxygen , mechanical ventilation , supplemental oxygen , oxygen saturation , low birth weight , birth weight , neonatal intensive care unit , anesthesia , ventilation (architecture) , oxygen , psychological intervention , randomized controlled trial , target range , pediatrics , surgery , pregnancy , nursing , mechanical engineering , chemistry , organic chemistry , macroeconomics , biology , engineering , economics , genetics
Abstract Aim Providing consistent levels of oxygen saturation (SpO 2 ) for infants in neonatal intensive care units is not easy. This study explored how effectively the Auto‐Mixer ® algorithm automatically adjusted fraction of inspired oxygen (FiO 2 ) levels to maintain SpO 2 within an intended range in extremely low birth weight infants receiving supplemental oxygen without mechanical ventilation. Methods Twenty extremely low birth weight infants were randomly assigned to the Auto‐Mixer ® group or the manual intervention group and studied for 12 h. The SpO 2 target was 85–93%, and the outcomes were the percentage of time SpO 2 was within target, SpO 2 variability, SpO 2 >95%, oxygen received and manual interventions. Results The percentage of time within intended SpO 2 was 58 ± 4% in the Auto‐Mixer ® group and 33.7 ± 4.7% in the manual group, SpO 2 >95% was 26.5% vs 54.8%, average SpO 2 and FiO 2 were 89.8% vs 92.2% and 37% vs 44.1%, and manual interventions were 0 vs 80 (p < 0.05). Brief periods of SpO 2 < 85% occurred more frequently in the Auto‐Mixer ® group. Conclusion The Auto‐Mixer ® effectively increased the percentage of time that SpO 2 was within the intended target range and decreased the time with high SpO 2 in spontaneously breathing extremely low birth weight infants receiving supplemental oxygen.