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Aim  To compare absolute values of regional cerebral tissue oxygenation (c S t O  2 ) during haemodynamic transition after birth and repeatability during steady state for two commercial near‐infrared spectroscopy ( NIRS ) devices.    Methods  In a prospective observational study, the  INVOS  5100 C  and  FORE ‐ SIGHT  were compared on 12 term newborns delivered by elective caesarean section. During the 10 min following umbilical cord clamping, c S t O  2  was measured simultaneously with the neonatal sensors from each device. Repeated measurements were taken the following day.    Results  Three and 8 min after clamping, the mean c S t O  2  value increased from 53.4% ( CI  36.8–69.9%) to 86.0% ( CI  80.2–91.7%) for  INVOS  and from 61.6% ( CI  55.4–67.8%) to 82.2% ( CI  77.7–86.7%) for  FORE ‐ SIGHT . The  B land– A ltman plot revealed decreasing difference ( INVOS  minus  FORE ‐ SIGHT ) (D) in absolute values (A) with increasing c S t O 2 ( D  = 0.5A – 38.19 p = <0.001). The mean steady‐state value on day two was 78.4% ( CI  74.6–82.2%) and 86.2% ( CI  85.0–87.4%) for  INVOS  and  FORE ‐ SIGHT , respectively. The within‐subject standard deviation during steady‐state repeated measurements was 4.8% ± 0.86 for  INVOS  and 2.8% ± 0.5 for  FORE ‐ SIGHT .    Conclusion  The  INVOS  and  FORE ‐ SIGHT  c S t O  2  estimates showed oxygenation‐level‐dependent difference during birth transition. The better repeatability of  FORE ‐ SIGHT  could be due to the lower response to change in saturation.

Cerebral oxygenation after birth – a comparison of INVOS ® and FORE ‐ SIGHT ™ near‐infrared spectroscopy oximeters