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Electroretinogram abnormalities in nonanterior childhood uveitis
Author(s) -
Brouwer Anna H.,
Genderen Maria. M.,
Wit Gerard C.,
Boer Joke H.
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13923
Subject(s) - erg , medicine , electroretinography , ophthalmology , uveitis , retinal , fluorescein angiography , visual acuity
Purpose A major point of concern in uveitis is the development of irreversible retinal changes after inflammation. In this study, we assess how nonanterior childhood uveitis affects retinal function using full‐field electroretinography ( ERG ). Methods Cross‐sectional study. ERG s of 63 uveitis eyes (33 children) were measured according to extended International Society for Clinical Electrophysiology of Vision ( ISCEV ) protocols. ERG abnormalities were investigated in relation to the following clinical parameters: demographics, uveitis characteristics, including severity of inflammation, treatment, best corrected visual acuity ( BCVA ), cystoid macular oedema ( CME ) on optical coherence tomography and fluorescein angiography score. Results The ERG showed abnormalities in 34 eyes (54%). The most frequent ERG abnormalities were prolonged implicit times of the cone b‐wave (37%; n = 23/63) and an abnormal 30‐Hz flicker response (implicit time and/or amplitude) (33%; n = 21/63). Factors associated with these ERG abnormalities were CME (p = 0.021) and 3+ vitreous cells (p = 0.021). BCVA in eyes with and without these ERG abnormalities did not statistically differ and was relatively good (median: 0.05 Log MAR , IQR : 0.00–0.15 Log MAR ). Conclusion The ERG is frequently affected in childhood uveitis indicating a global retinal dysfunction. ERG abnormalities seem to be associated with a more severe posterior segment inflammation and a younger age. If an association between ERG abnormalities and long‐term visual outcome can be made in the future, these early ERG findings during the course of childhood uveitis have significance for treatment strategies.