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Purpose  To study the association of the single nucleotide polymorphism ( SNP ) rs4073 in the  interleukin‐8 ( IL ‐8)  promoter region with the diagnosis and age of onset of exudative age‐related macular degeneration ( AMD ) in association with the known genetic risk factors for  AMD  and tobacco smoking.    Methods  Medical records, smoking history and angiograms or fundus photographs of 301 patients with exudative  AMD , 72 patients with dry  AMD  and 119 control subjects were analysed retrospectively. The associations of   IL ‐8  rs4073 A→T,   CFH   rs1061170 T→C,   ARMS 2  rs10490924 G→T and  C3  rs2230199 C→G  SNP s with the presence of  AMD  and with the age of onset of exudative  AMD  were analysed.    Results  Younger age of exudative  AMD  onset was associated with the homozygous  AA  genotype of   IL ‐8  rs4073 (p = 0.009, Mann–Whitney  U ‐test),  CC  genotype of   CFH   rs1061170 (p = 0.016),  TT  genotype of   ARMS 2  rs10490924 (p = 0.001) and with current smoking (p = 0.002). The risk alleles C in   CFH   rs1061170 (p < 0.0001, Pearson chi‐square) and T in   ARMS 2  rs10490924 (p < 0.0001), as well as smoking (p < 0.0001), were more prevalent in  AMD  patients compared with controls. No association was found between the   IL ‐8  rs4073 genotype and the presence of  AMD .    Conclusion  Out of the factors associated with the earlier onset of exudative  AMD , only the genotype of   IL ‐8  rs4073 did not appear as a risk factor for  AMD  in general.  IL ‐8 may have a role in accelerating the development of the choroidal neovascularization in exudative  AMD .

acta ophthalmologica

The genetic variant rs4073 A→T of the  Interleukin‐8  promoter region is associated with the earlier onset of exudative age‐related macular degeneration