Premium
The genetic variant rs4073 A→T of the Interleukin‐8 promoter region is associated with the earlier onset of exudative age‐related macular degeneration
Author(s) -
Hautamäki Asta,
Seitsonen Sanna,
Holopainen Juha M.,
Moilanen Jukka A.,
Kivioja Jarno,
Onkamo Päivi,
Järvelä Irma,
Immonen Ilkka
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12799
Subject(s) - genotype , medicine , macular degeneration , single nucleotide polymorphism , gastroenterology , snp , allele , risk factor , ophthalmology , genetics , gene , biology
Purpose To study the association of the single nucleotide polymorphism ( SNP ) rs4073 in the interleukin‐8 ( IL ‐8) promoter region with the diagnosis and age of onset of exudative age‐related macular degeneration ( AMD ) in association with the known genetic risk factors for AMD and tobacco smoking. Methods Medical records, smoking history and angiograms or fundus photographs of 301 patients with exudative AMD , 72 patients with dry AMD and 119 control subjects were analysed retrospectively. The associations of IL ‐8 rs4073 A→T, CFH rs1061170 T→C, ARMS 2 rs10490924 G→T and C3 rs2230199 C→G SNP s with the presence of AMD and with the age of onset of exudative AMD were analysed. Results Younger age of exudative AMD onset was associated with the homozygous AA genotype of IL ‐8 rs4073 (p = 0.009, Mann–Whitney U ‐test), CC genotype of CFH rs1061170 (p = 0.016), TT genotype of ARMS 2 rs10490924 (p = 0.001) and with current smoking (p = 0.002). The risk alleles C in CFH rs1061170 (p < 0.0001, Pearson chi‐square) and T in ARMS 2 rs10490924 (p < 0.0001), as well as smoking (p < 0.0001), were more prevalent in AMD patients compared with controls. No association was found between the IL ‐8 rs4073 genotype and the presence of AMD . Conclusion Out of the factors associated with the earlier onset of exudative AMD , only the genotype of IL ‐8 rs4073 did not appear as a risk factor for AMD in general. IL ‐8 may have a role in accelerating the development of the choroidal neovascularization in exudative AMD .