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Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ventricular assist device ( LVAD )  H eart M ate  II  ( HMII ) ( T horatec  C orporation,  I nc.,  P leasanton, CA,  USA ) and detect changes in sound signals correlating to clots in the inflow, outflow, and pump housing. Using modern telecom techniques, it was possible to register and analyze the  HMII  pump‐specific acoustic fingerprint in an experimental model of  LVAD  support using a mock loop. Increase in pump speed significantly ( P  < 0.005) changed the acoustic fingerprint at certain frequency (0–23 000  Hz ) intervals (regions:  R 1–3 and peaks:  P 1,3–4). When the ball valves connected to the tubing were narrowed sequentially by ∼50% of the inner diameter (to mimic clot in the out‐ and inflow tubing), the frequency spectrum changed significantly ( P  < 0.005) in  P 1 and  P 2 and  R 1 when the outflow tubing was narrowed. This change was not seen to the same extent when the lumen of the ball valve connected to the inflow tube was narrowed by ∼50%. More significant ( P  < 0.005) acoustic changes were detected in  P 1 and  P 2 and  R 1 and  R 3, with the largest  dB  figs. in the lower frequency ranges in  R 1 and  P 2, when artificial clots and blood clots passed through the pump system. At higher frequencies, a significant change in  dB  figs. in  R 3 and  P 4 was detected when clots passed through the pump system. Acoustic monitoring of pump sounds may become a valuable tool in  LVAD  surveillance.

Acoustic Analysis of a Mechanical Circulatory Support