Open AccessEvaluation of repeat testing of a non‐sequencing based NIPT test on a Finnish general‐risk population
Author(s) -
Karlsson Filip,
Ahola Tarja,
Dahlberg Jenny,
Prensky Lawrence,
Moilanen Helena,
Spalding Heli
Publication year - 2021
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.14125
Subject(s) - medicine , test (biology) , population , environmental health , biology , paleontology
To evaluate the effect of repeating test failures using an automated, non‐sequencing based non‐invasive prenatal testing test on a general‐risk population in Finland. Material and Methods A total of 545 samples from women who represent the average‐risk population in Oulu, Finland were analyzed with Vanadis ® non‐invasive prenatal testing. Repeat testing of test failures was performed using a second sample. Results before and after repeat testing were compared with the reference outcome, as determined by clinical examination of neonates. Results There were eight test failures after first‐pass analysis, representing 1.5% of samples (95% CI 0.6%‐2.9%). Seven out of eight failures could be resolved by analysis of a second sample, thereby reducing the test failure rate from 1.5% to 0.2% (95% CI 0.0%‐1.0%). Conclusions Repeating test failures with a second plasma sample could significantly reduce the effective failure rate, thereby providing a way to effectively minimize test failures and further improving clinical utility and test performance.