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For women with chronic or gestational hypertension in  CHIPS  (Control of Hypertension In Pregnancy Study, NCT01192412), we aimed to examine whether clinical predictors collected at randomization could predict adverse outcomes.    Material and methods  This was a planned, secondary analysis of data from the 987 women in the  CHIPS  Trial. Logistic regression was used to examine the impact of 19 candidate predictors on the probability of adverse perinatal (pregnancy loss or high level neonatal care for >48 h, or birthweight <10th percentile) or maternal outcomes (severe hypertension, preeclampsia, or delivery at <34 or <37 weeks). A model containing all candidate predictors was used to start the stepwise regression process based on goodness of fit as measured by the Akaike information criterion. For face validity, these variables were forced into the model: treatment group (“less tight” or “tight” control), antihypertensive type at randomization, and blood pressure within 1 week before randomization. Continuous variables were represented continuously or dichotomized based on the smaller  p ‐value in univariate analyses. An area‐under‐the‐receiver‐operating‐curve ( AUC ROC ) of ≥0.70 was taken to reflect a potentially useful model.    Results  Point estimates for  AUC ROC  were <0.70 for all but severe hypertension (0.70, 95% CI 0.67–0.74) and delivery at <34 weeks (0.71, 95% CI 0.66–0.75). Therefore, no model warranted further assessment of performance.    Conclusions   CHIPS  data suggest that when women with chronic hypertension develop an elevated blood pressure in pregnancy, or formerly normotensive women develop new gestational hypertension, maternal and current pregnancy clinical characteristics cannot predict adverse outcomes in the index pregnancy.

acta obstetricia et gynecologica scandinavica

Can adverse maternal and perinatal outcomes be predicted when blood pressure becomes elevated? Secondary analyses from the  CHIPS  (Control of Hypertension In Pregnancy Study) randomized controlled trial