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The association of pre‐operative anaemia with survival after orthotopic liver transplantation
Author(s) -
Lichtenegger P.,
Schiefer J.,
Graf A.,
Berlakovich G.,
Faybik P.,
Baron D. M.,
BaronStefaniak J.
Publication year - 2020
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.14918
Subject(s) - medicine , orthotopic liver transplantation , liver transplantation , transplantation , surgery
Summary Anaemia is common in patients with end‐stage liver disease. Pre‐operative anaemia is associated with greater mortality after major surgery. We analysed the association of pre‐operative anaemia (World Health Organization classification) with survival and complications after orthotopic liver transplantation using Cox and logistic regression models. We included patients undergoing their first orthotopic liver transplantation between 2004 and 2016. Out of 599 included patients, 455 (76%) were anaemic before transplantation. Pre‐operative anaemia was not associated with the survival of 485/599 (81%) patients to 1 year after liver transplantation, OR (95% CI ) 1.04 (0.64–1.68), p = 0.88. Pre‐operative anaemia was associated with higher rates of intra‐operative blood transfusions and acute postoperative kidney injury on multivariable analysis, OR (95% CI ) 1.70 (0.82–2.59) and 1.72 (1.11–2.67), respectively, p < 0.001 for both. Postoperative renal replacement therapy was associated with pre‐operative anaemia on univariate analysis, OR (95% CI ) 1.87 (1.11–3.15), p = 0.018.