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A randomised controlled trial of peri‐operative lidocaine infusions for open radical prostatectomy
Author(s) -
Weinberg L.,
Rachbuch C.,
Ting S.,
Howard W.,
Yeomans M.,
Gordon I.,
McNicol L.,
James K.,
Story D.,
Christophi C.
Publication year - 2016
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/anae.13368
Subject(s) - medicine , lidocaine , anesthesia , saline , bolus (digestion) , prostatectomy , morphine , surgery , prostate , cancer
Summary We allocated 76 men scheduled for radical retropubic prostatectomy to peri‐operative lidocaine 2% or saline 0.9%: a pre‐operative 0.075 ml.kg −1 intravenous bolus; an intra‐operative intravenous infusion at 0.075 ml.kg −1 .h −1 ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg −1 .h −1 . Lidocaine reduced the postoperative hospital stay by a mean (95% CI ) of 1.3 (0.3–2.4) days, p = 0.017, from a mean ( SD ) of 4.6 (3.2) days with saline. Lidocaine reduced pain at rest during the first 24 postoperative hours by a mean (95% CI ) of 1.8 (0.7–2.9) mm.h −1 , p = 0.001. Lidocaine reduced 24‐h morphine consumption by a mean (95% CI ) of 13.9 (2.2–25.7) mg, p = 0.021, from a mean ( SD ) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.